PENGARUH PEMBERIAN EKSTRAK BUAH MERAH (Pandanus conoideus) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) DIABETIK

Abstract

This research was conducted to determine the effect of extract of buah merah (Pandanus conoideus) on blood
glucose levels in rats (Rattus norvegicus) diabetic. The samples used were 20 male Wistar rats, aged 2 months and weighed
160-180 grams were divided into four groups randomly each of five rats. I as a normal control group were given distilled
water, 1 ml / head / day / orally, group II as control of alloxan, alloxan injected dose of 140 mg / kg bw / ip on day 2, group III
were injected with alloxan 140 mg / kg bw / ip on day-to-two, was given a dose of buah merah extract 4 g / kg bw / day /
orally day 3 until day 21, group IV injected with alloxan dose of 140 mg / kg bw / ip on days 2 and extract buah merah dose
17 g / kg bw / day / orally day 3 until day 21. Blood glucose levels checked for day-to-0, 3, 6, 10, 14, and 22. Blood glucose
data were analyzed statistically by using analysis of variance (ANOVA) of One Way Anova, followed by the Tukey-test and
LSD test. The results after 24 hours were given alloxan (day 3) an increase in blood glucose levels significantly (p <0.05) in
group II, III, and IV compared with group I (control). After treatment with buah merah extract in group III and IV decreased
glucose levels (p <0.05) on day 6 until the last day of the study (day 22).From the research, buah merah extract dose 4 g / kg
bw / day / orally and 17 g / kg bw / day / orally can decrease blood glucose levels in diabetic rats (p <0.05).